If a person uses a limb of his body to perform a mitzvah in this world, Hashem’s radiance will rest upon that limb in the World to Come.  However, if he forsakes one of the 248 positive commandments (which correspond to the 248 limbs of the body, and does not do teshuva (repent), then his soul will lack the corresponding spiritual “limb” in the World to Come.

Therefore, if a person joins the ranks of those who speak lashon hara, and gives free rein to his mouth and ears to speak and hear lashon hara, he will punished in the World to Come by having these faculties impaired. ~ Shemiras HaLashon