“It states (Tehillim 145:18) קָרוֹב יְהוָה, לְכָל-קֹרְאָיו לְכֹל אֲשֶׁר יִקְרָאֻהוּ בֶאֱמֶת, ‘Hashem is close to those who pray to Him with truth.’ What does it mean, to pray to Hashem with truth? When one knows there’s nowhere to turn other than to Hashem, that is a true prayer. Then
קָרוֹב יְהוָה, Hashem is close and He listens to your tefillos…”

The Leshem told this to his daughter who was crying after being told by doctors that she cannot have children.  A year later she gave birth to a baby who one day would become the gadol haDor, R’ Eliyashiv zt”l.